Thursday, September 30, 2010
Weight Loss Secret Revealed
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Hi, I’m Fadi Malouf, Atlanta’s top fitness expert,
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•How to take control of your slow metabolism.
•Why your current exercise program may be failing you.
•The big myth about resistance training.
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Do You Want the Free "Weight Loss Secrets Revealed" Report Only? Just follow these 3 steps:
1. Visit www.MyFitnessSolution.com
2. Look to the left for red box and Click on "Free Trial" for our Web Based Health & Fitness Tools
3. Mention this Craigslist Ad to receive your Free Weight Loss Secrets Revealed Report
Act now because this no obligation offer expires on October 17th by midnight.
Hi, I’m Fadi Malouf, Atlanta’s top fitness expert,
Why would I reveal weight loss secrets that only the top personal trainers in the industry know? It’s simple really…because I know that once you discover these three key strategies for achieving the results that you desire– you’ll keep coming back to me for all your health, fitness, and weight loss needs.
Here’s just a few things you’ll discover:
•How to take control of your slow metabolism.
•Why your current exercise program may be failing you.
•The big myth about resistance training.
How to take advantage of this offer:
1. Visit www.MyFitnessSolution.com
2. Look to the left for red box and Click on "New User"
3. Accept terms and Choice 90-Day Online Health & Fitness Program to begin your registration
4. Use Promo code "REVEALED" to receive 76% Off your Custom Health & Fitness program, receive the "Weight Loss Secrets Revealed" report for free and personally speak with Veteran Fitness Expert Fadi Malouf!
In 5 Minutes You Can Have:
1. The "Weight Loss Secrets Revealed" Report
2. Your Personalized 90-Day Health & Fitness Program from our team of Wellness Experts, Phd Doctor and Registered Nutritionist
3. Personal Phone Conversation with Fitness and Weight Loss Expert Fadi Malouf
A Total Value Of $297 - Act Now To Purchase for Only $35
Do You Want the Free "Weight Loss Secrets Revealed" Report Only? Just follow these 3 steps:
1. Visit www.MyFitnessSolution.com
2. Look to the left for red box and Click on "Free Trial" for our Web Based Health & Fitness Tools
3. Mention this Craigslist Ad to receive your Free Weight Loss Secrets Revealed Report
Act now because this no obligation offer expires on October 17th by midnight.
Jump Squats
Benefits and Application of Jump Squats |
One exercise I am frequently asked about is jump squats. I use jump squats fairly often with athletes because they are quite a versatile movement and can be used to accomplish quite a few different things. They can build strength-speed, build power, improve rate of force development, and of course build up plyometric capacities. In addition they can be used at the beginning of a workout for no other purpose then to increase muscle motor unit recruitment and enhance subsequent strength work. Try this sometime. When you're warming up for a squat workout progressively add load to the bar until you complete your last warm-up set. Then drop the weight down and knock out a set of jump squats. Say you're warming up for a working set of 300 x 5 - your entire warm-up might look something like this: 45 x 10 135 x 7 225 x 5 275 x 3 300 x 1 325 x 1 Jump Squat- 115 x 10 300 x 5- (work set) The high speed movement will fire up your nervous system thus increasing neural output and muscle recruitment. This will make the heavier load feel lighter then normal. This same scheme can also be used when preparing for a 1 rm attempt. In fact, the same sort've protocol can be used with the bench press but obviously a speed bench, bench throw, or upper body depth jump would replace the jump squat. Specific Applications of The Jump Squat Now let me talk about and show you some more specific uses for the jump squat. I incorporate the jump squat quite often into routines for explosive development. The loading will vary and so will the movement performance and benefits. We can customize the loading to the athletes sporting requirements and needs. A powerlifter needs to work more on the strength side of the power spectrum while a speed athlete needs more work on the speed side. This means someone like a powerlifter or lineman can benefit from heavier loads. By varying the load and the way the movement is performed we can focus on strength/speed or speed/strength. Strength-Speed- Requires a combination of strength and speed with strength being a little more dominant. The loading will be 50% 1rm or greater which obviously requires more strength then a lighter load. Speed-Strength- Requires a combination of speed and strength with speed being the dominant quality. The loading will range from 15-40% 1rm which requires more speed. In addition, we can also use Jump Squats to build reactive strength, starting strength, or rate of force development. A lineman or powerlifter might perform jump squats with loads in the 40-60% range since they have to be explosive while moving around loads. A sprinter might work in the 15-40% range and initiate the jump out of a pause in the bottom position to build superior explosive strength and rate of force development, qualities which are necessary for the start of a sprint. An Ideal Force Curve Movements like running or jumping are characterized by 2 peaks of force. The first peak occurs during the transition phase. The transition phase is the reverse of direction from down to up that occurs as the foot hits the ground in the sprint, or the transition from down to up that occurs during the countermovement of a vertical jump. What occurs after this first peak of force is crucial. An athlete should move harmoniously out of the transition and then build up to another peak of force that occurs at toe off. This is known as the triple extension phase and it occurs as one extends the joints of the ankles, knees, and hips simultaneously and the body is projected into the air. One advantage of a jump squat is they enable a person to train and develop this peak of force that occurs with triple extension. Regular squats and "strength" lifts will help develop the first force peak, the one that occurs at the transition from down to up. However, because the movement slows down during the ascent and movement is terminated before the triple extension phase up top, - they don't develop the 2nd force peak that occurs as one builds up velocity and force at toe off. In fact, over a period of time, many loaded movements can hamper this function because they can program a person to stop or terminate force just as they reach the triple extension phase. It should be noted, however, that before you can develop the 2nd force peak you have to develop the first one. That is, without a base of strength then all the jump squats in the world won't do much for you. The advantage of jump squats is they enable you to demonstrate the type of force curve that occurs with explosive sporting movements. The Olympic Lifts and Triple Extension The olympic lifts (snatch and clean) are often presribed in sports training programs because of their ability to train the triple extension that occurs during the pulling phase. This triple extension not only mimicks the action of explosive sports movements but also develops whole body explosiveness and power, particularly in the lower body. The trouble with the olympic lifts is they do require a strong technical component. Qualified coaches are in short supply and the movements can be difficult to learn correctly. Fortunately, we can get the same benefits with jump squats that we can with olympic lifts. In fact, since jump squats enable one to zero in on the triple extension phase, we can benefit from them to an even greater extent. We can customize the movement and load to train varying strength qualities needed for sports performance. Another advantage of the jump squat is it can be learned in 5 minutes or less. Types of Jump Squats I like to use 4 different types of jump squats. These are a 1/4 rhythmic jump squat, a paused full jump squat, a reactive full jump squat, and a 1/4 jump squat with reset. 1/4 rhythmic jump squat- This jump squat variation is performed rhythmically with each jump occuring immediately after the next. The performance will be just like the vertical jump, the only difference is you will have a load on your back. This variation is most effective for reactive development and to peak the vertical jump. You should quickly descend down into a 1/4 squat position and try to jump as high as possible on the ascent - focus on driving the balls of your feet through the floor at toe-off. As soon as you land you should immediately perform another jump. The loading should be 15-40% of max 1rm with anywhere from 5-15 repetitions per set. paused jump squat- This variation of the jump squat calls for a deeper knee bend. Instead of only descending into a 1/4 squat position you go down into a 1/2 squat position with your thighs roughly parallel to the floor. From here, you use a 3-5 second pause and then explode up forcefully once again driving through the balls of the feet at toe-off. This variation is great for training explosive strength and rate of force development. The lack of reflexive plyometric rebound at the bottom emphasizes explosive voluntary force. It is a great movement to help develop the start of a sprint. Loading should be 15-50% of max squat with anywhere from 3-8 reps per set. reactive squat- In this variation the focus is just as much on the negative eccentric contraction as it is on the "jump". Hold the weight tight against your shoulders and drop quickly from top to bottom. Focus on accelerating during the negative (down) phase so that you build up a lot of mechanical tension during the eccentric to concentric switch that occurs at the bottom. Your hips will get fairly low, somewhere around parallel. When getting started, think of finding the point where you get stretch reflexes from as many muscle groups as possible (glutes, hamstrings, quads, calves, etc). Get low enough to accomplish this. After you relax and free fall you then quickly gain full tension to stabilize the force of the load at the bottom. This will develop explosive power in the entire lower body musculature and teach you to really turn on the power. If all is done correctly you should feel your body want to rebound to the top after the initation of force absorption at the bottom. You should feel your body respond with a reflexive "bounce" at the bottom. It can be beneficial to just focus on the negative part with lighter loads until you get the hang of the movement. Once you do, simply carry the reflex out of the bottom all the way to the top and jump. Reset yourself for each repetition. The loading on this variation will be between 30-60% of max squat depending on the goals and needs of the athlete. The rep range will fall between 3-10 per set. 1/4 jump squat with reset- This variation is just like the rhythmic jump squat except you reset yourself prior to each repetition. This will enable you to fully concentrate on each repetition. So, on these, just like the rhythmic jump squat, the focus is on the takeoff and getting as high as possible. The performance will be just like the vertical jump the only difference is you will have load on your back. I prefer to use this variation most of the time. The loading will range anywhere from 15-60% again depending on the athlete. Heavier variations are used to develop more strength-speed and lighter variations for more speed-strength. The rep range will be anywhere from 3-8 per set with an average of 5 sets per session. Now for a workout incorporating jump squats aimed at improving vertical jump capacities try this: Session 1 Reactive Squat- 50% of max squat 5 x 5 Squat 4 x 5 (80%) Session 2 1/4 rhythmic jump squat - 4 x 10 (20%) Deadlift- 4 x 4 (80%) Session 3 Paused Jump Squat- 5 x 4 (30% - 3 second pause) 1/4 Jump Squat with reset- 4 x 5 (40%) Session 4 1/4 Jump Squat with reset- 4 x 5 (30%) Depth Jump - 6 x 4 (18-inch box height) Session 5 Test Vertical Jump Rest 3 days in between each session. Give some of these variations a try and you'll be pleasantly surprised. Source: www.Vertcoach.com |
Tuesday, September 28, 2010
Insulin Resistance and Pre-Diabete
What is insulin resistance?
Insulin resistance is a condition in which the body produces insulin but does not use it properly. Insulin, a hormone made by the pancreas, helps the body use glucose for energy. Glucose is a form of sugar that is the body’s main source of energy.
The body’s digestive system breaks food down into glucose, which then travels in the bloodstream to cells throughout the body. Glucose in the blood is called blood glucose, also known as blood sugar. As the blood glucose level rises after a meal, the pancreas releases insulin to help cells take in and use the glucose.
When people are insulin resistant, their muscle, fat, and liver cells do not respond properly to insulin. As a result, their bodies need more insulin to help glucose enter cells. The pancreas tries to keep up with this increased demand for insulin by producing more. Eventually, the pancreas fails to keep up with the body’s need for insulin. Excess glucose builds up in the bloodstream, setting the stage for diabetes. Many people with insulin resistance have high levels of both glucose and insulin circulating in their blood at the same time.
Insulin resistance increases the chance of developing type 2 diabetes and heart disease. Learning about insulin resistance is the first step toward making lifestyle changes that can help prevent diabetes and other health problems.
What causes insulin resistance?
Scientists have identified specific genes that make people more likely to develop insulin resistance and diabetes. Excess weight and lack of physical activity also contribute to insulin resistance.
Many people with insulin resistance and high blood glucose have other conditions that increase the risk of developing type 2 diabetes and damage to the heart and blood vessels, also called cardiovascular disease. These conditions include having excess weight around the waist, high blood pressure, and abnormal levels of cholesterol and triglycerides in the blood. Having several of these problems is called metabolic syndrome or insulin resistance syndrome, formerly called syndrome X.
Metabolic Syndrome
Metabolic syndrome is defined as the presence of any three of the following conditions:
- waist measurement of 40 inches or more for men and 35 inches or more for women
- triglyceride levels of 150 milligrams per deciliter (mg/dL) or above, or taking medication for elevated triglyceride levels
- HDL, or “good,” cholesterol level below 40 mg/dL for men and below 50 mg/dL for women, or taking medication for low HDL levels
- blood pressure levels of 130/85 or above, or taking medication for elevated blood pressure levels
- fasting blood glucose levels of 100 mg/dL or above, or taking medication for elevated blood glucose levels
Source: Grundy SM, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation. 2005;112:2735–2752.
Similar definitions have been developed by the World Health Organization and the American Association of Clinical Endocrinologists.
What is pre-diabetes?
Pre-diabetes is a condition in which blood glucose levels are higher than normal but not high enough for a diagnosis of diabetes. This condition is sometimes called impaired fasting glucose (IFG) or impaired glucose tolerance (IGT), depending on the test used to diagnose it. The U.S. Department of Health and Human Services estimates that about one in four U.S. adults aged 20 years or older—or 57 million people—had pre-diabetes in 2007.
People with pre-diabetes are at increased risk of developing type 2 diabetes, formerly called adult-onset diabetes or noninsulin-dependent diabetes. Type 2 diabetes is sometimes defined as the form of diabetes that develops when the body does not respond properly to insulin, as opposed to type 1 diabetes, in which the pancreas makes little or no insulin.
Studies have shown that most people with pre-diabetes develop type 2 diabetes within 10 years, unless they lose 5 to 7 percent of their body weight—about 10 to 15 pounds for someone who weighs 200 pounds—by making changes in their diet and level of physical activity. People with pre-diabetes also are at increased risk of developing cardiovascular disease.
What are the symptoms of insulin resistance and pre-diabetes?
Insulin resistance and pre-diabetes usually have no symptoms. People may have one or both conditions for several years without noticing anything. People with a severe form of insulin resistance may have dark patches of skin, usually on the back of the neck. Sometimes people have a dark ring around their neck. Other possible sites for dark patches include elbows, knees, knuckles, and armpits. This condition is called acanthosis nigricans.
How are insulin resistance and pre-diabetes diagnosed?
Health care providers use blood tests to determine whether a person has pre-diabetes but do not usually test for insulin resistance. Insulin resistance can be assessed by measuring the level of insulin in the blood. However, the test that most accurately measures insulin resistance, called the euglycemic clamp, is too costly and complicated to be used in most doctors’ offices. The clamp is a research tool used by scientists to learn more about glucose metabolism. If tests indicate pre-diabetes or metabolic syndrome, insulin resistance most likely is present.
Diabetes and pre-diabetes can be detected with one of the following tests:
Fasting glucose test. This test measures blood glucose in people who have not eaten anything for at least 8 hours. This test is most reliable when done in the morning. Fasting glucose levels of 100 to 125 mg/dL are above normal but not high enough to be called diabetes. This condition is called pre-diabetes or IFG. People with IFG often have had insulin resistance for some time. They are much more likely to develop diabetes than people with normal blood glucose levels.
Glucose tolerance test. This test measures blood glucose after people fast for at least 8 hours and 2 hours after they drink a sweet liquid provided by a doctor or laboratory. A blood glucose level between 140 and 199 mg/dL means glucose tolerance is not normal but is not high enough for a diagnosis of diabetes. This form of pre-diabetes is called IGT and, like IFG, it points toward a history of insulin resistance and a risk for developing diabetes.
People whose test results indicate they have pre-diabetes should have their blood glucose levels checked again in 1 to 2 years.
Risk Factors for Pre-diabetes and Type 2 Diabetes
The American Diabetes Association recommends that testing to detect pre-diabetes and type 2 diabetes be considered in adults without symptoms who are overweight or obese and have one or more additional risk factors for diabetes. In those without these risk factors, testing should begin at age 45.
Risk factors for pre-diabetes and diabetes—in addition to being overweight or obese or being age 45 or older—include the following:
- being physically inactive
- having a parent or sibling with diabetes
- having a family background that is African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, or Pacific Islander
- giving birth to a baby weighing more than 9 pounds or being diagnosed with gestational diabetes—diabetes first found during pregnancy
- having high blood pressure—140/90 or above—or being treated for high blood pressure
- having an HDL, or “good,” cholesterol level below 35 mg/dL or a triglyceride level above 250 mg/dL
- having polycystic ovary syndrome, also called PCOS
- having impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) on previous testing
- having other conditions associated with insulin resistance, such as severe obesity or acanthosis nigricans
- having a history of cardiovascular disease
If test results are normal, testing should be repeated at least every 3 years. Health care providers may recommend more frequent testing depending on initial results and risk status.
Can insulin resistance and pre-diabetes be reversed?
Yes. Physical activity and weight loss help the body respond better to insulin. By losing weight and being more physically active, people with insulin resistance or pre-diabetes may avoid developing type 2 diabetes.
The Diabetes Prevention Program (DPP) and other large studies have shown that people with pre-diabetes can often prevent or delay diabetes if they lose a modest amount of weight by cutting fat and calorie intake and increasing physical activity—for example, walking 30 minutes a day 5 days a week. Losing just 5 to 7 percent of body weight prevents or delays diabetes by nearly 60 percent. In the DPP, people aged 60 or older who made lifestyle changes lowered their chances of developing diabetes by 70 percent. Many participants in the lifestyle intervention group returned to normal blood glucose levels and lowered their risk for developing heart disease and other problems associated with diabetes. The DPP also showed that the diabetes drug metformin reduced the risk of developing diabetes by 31 percent.
People with insulin resistance or pre-diabetes can help their body use insulin normally by being physically active, making wise food choices, and reaching and maintaining a healthy weight. Physical activity helps muscle cells use blood glucose for energy by making the cells more sensitive to insulin.
Body Mass Index (BMI)
BMI is a measurement of body weight relative to height. Adults aged 20 or older can use the BMI table below to find out whether they are normal weight, overweight, obese, or extremely obese. To use the table, follow these steps:
- Find the person’s height in the left-hand column.
- Move across the row to the number closest to that person’s weight.
- Check the number at the top of that column.
The number at the top of the column is the person’s BMI. The words above the BMI number indicate whether the person is normal weight, overweight, obese, or extremely obese. People who are overweight, obese, or extremely obese should consider talking with a doctor about ways to lose weight to reduce the risk of diabetes.
The BMI table has certain limitations. It may overestimate body fat in athletes and others who have a muscular build and underestimate body fat in older adults and others who have lost muscle. BMI for children and teens must be determined based on age and sex in addition to height and weight. Information about BMI in children and teens, including a BMI calculator, is available from the Centers for Disease Control and Prevention (CDC) at www.cdc.gov/nccdphp/dnpa/bmi. The CDC website also has a BMI calculator for adults.
Body Mass Index Table
Printer-friendly version *Normal | Overweight | Obese | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BMI | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 |
Height (inches) | Body Weight (pounds) | ||||||||||||||||
58 | 91 | 96 | 100 | 105 | 110 | 115 | 119 | 124 | 129 | 134 | 138 | 143 | 148 | 153 | 158 | 162 | 167 |
59 | 94 | 99 | 104 | 109 | 114 | 119 | 124 | 128 | 133 | 138 | 143 | 148 | 153 | 158 | 163 | 168 | 173 |
60 | 97 | 102 | 107 | 112 | 118 | 123 | 128 | 133 | 138 | 143 | 148 | 153 | 158 | 163 | 168 | 174 | 179 |
61 | 100 | 106 | 111 | 116 | 122 | 127 | 132 | 137 | 143 | 148 | 153 | 158 | 164 | 169 | 174 | 180 | 185 |
62 | 104 | 109 | 115 | 120 | 126 | 131 | 136 | 142 | 147 | 153 | 158 | 164 | 169 | 175 | 180 | 186 | 191 |
63 | 107 | 113 | 118 | 124 | 130 | 135 | 141 | 146 | 152 | 158 | 163 | 169 | 175 | 180 | 186 | 191 | 197 |
64 | 110 | 116 | 122 | 128 | 134 | 140 | 145 | 151 | 157 | 163 | 169 | 174 | 180 | 186 | 192 | 197 | 204 |
65 | 114 | 120 | 126 | 132 | 138 | 144 | 150 | 156 | 162 | 168 | 174 | 180 | 186 | 192 | 198 | 204 | 210 |
66 | 118 | 124 | 130 | 136 | 142 | 148 | 155 | 161 | 167 | 173 | 179 | 186 | 192 | 198 | 204 | 210 | 216 |
67 | 121 | 127 | 134 | 140 | 146 | 153 | 159 | 166 | 172 | 178 | 185 | 191 | 198 | 204 | 211 | 217 | 223 |
68 | 125 | 131 | 138 | 144 | 151 | 158 | 164 | 171 | 177 | 184 | 190 | 197 | 203 | 210 | 216 | 223 | 230 |
69 | 128 | 135 | 142 | 149 | 155 | 162 | 169 | 176 | 182 | 189 | 196 | 203 | 209 | 216 | 223 | 230 | 236 |
70 | 132 | 139 | 146 | 153 | 160 | 167 | 174 | 181 | 188 | 195 | 202 | 209 | 216 | 222 | 229 | 236 | 243 |
71 | 136 | 143 | 150 | 157 | 165 | 172 | 179 | 186 | 193 | 200 | 208 | 215 | 222 | 229 | 236 | 243 | 250 |
72 | 140 | 147 | 154 | 162 | 169 | 177 | 184 | 191 | 199 | 206 | 213 | 221 | 228 | 235 | 242 | 250 | 258 |
73 | 144 | 151 | 159 | 166 | 174 | 182 | 189 | 197 | 204 | 212 | 219 | 227 | 235 | 242 | 250 | 257 | 265 |
74 | 148 | 155 | 163 | 171 | 179 | 186 | 194 | 202 | 210 | 218 | 225 | 233 | 241 | 249 | 256 | 264 | 272 |
75 | 152 | 160 | 168 | 176 | 184 | 192 | 200 | 208 | 216 | 224 | 232 | 240 | 248 | 256 | 264 | 272 | 279 |
76 | 156 | 164 | 172 | 180 | 189 | 197 | 205 | 213 | 221 | 230 | 238 | 246 | 254 | 263 | 271 | 279 | 287 |
Obese | Extreme Obesity | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BMI | 36 | 37 | 38 | 39 | 40 | 41 | 42 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | 51 | 52 | 53 | 54 | ||
Height (inches) | Body Weight (pounds) | ||||||||||||||||||||
58 | 172 | 177 | 181 | 186 | 191 | 196 | 201 | 205 | 210 | 215 | 220 | 224 | 229 | 234 | 239 | 244 | 248 | 253 | 258 | ||
59 | 178 | 183 | 188 | 193 | 198 | 203 | 208 | 212 | 217 | 222 | 227 | 232 | 237 | 242 | 247 | 252 | 257 | 262 | 267 | ||
60 | 184 | 189 | 194 | 199 | 204 | 209 | 215 | 220 | 225 | 230 | 235 | 240 | 245 | 250 | 255 | 261 | 266 | 271 | 276 | ||
61 | 190 | 195 | 201 | 206 | 211 | 217 | 222 | 227 | 232 | 238 | 243 | 248 | 254 | 259 | 264 | 269 | 275 | 280 | 285 | ||
62 | 196 | 202 | 207 | 213 | 218 | 224 | 229 | 235 | 240 | 246 | 251 | 256 | 262 | 267 | 273 | 278 | 284 | 289 | 295 | ||
63 | 203 | 208 | 214 | 220 | 225 | 231 | 237 | 242 | 248 | 254 | 259 | 265 | 270 | 278 | 282 | 287 | 293 | 299 | 304 | ||
64 | 209 | 215 | 221 | 227 | 232 | 238 | 244 | 250 | 256 | 262 | 267 | 273 | 279 | 285 | 291 | 296 | 302 | 308 | 314 | ||
65 | 216 | 222 | 228 | 234 | 240 | 246 | 252 | 258 | 264 | 270 | 276 | 282 | 288 | 294 | 300 | 306 | 312 | 318 | 324 | ||
66 | 223 | 229 | 235 | 241 | 247 | 253 | 260 | 266 | 272 | 278 | 284 | 291 | 297 | 303 | 309 | 315 | 322 | 328 | 334 | ||
67 | 230 | 236 | 242 | 249 | 255 | 261 | 268 | 274 | 280 | 287 | 293 | 299 | 306 | 312 | 319 | 325 | 331 | 338 | 344 | ||
68 | 236 | 243 | 249 | 256 | 262 | 269 | 276 | 282 | 289 | 295 | 302 | 308 | 315 | 322 | 328 | 335 | 341 | 348 | 354 | ||
69 | 243 | 250 | 257 | 263 | 270 | 277 | 284 | 291 | 297 | 304 | 311 | 318 | 324 | 331 | 338 | 345 | 351 | 358 | 365 | ||
70 | 250 | 257 | 264 | 271 | 278 | 285 | 292 | 299 | 306 | 313 | 320 | 327 | 334 | 341 | 348 | 355 | 362 | 369 | 376 | ||
71 | 257 | 265 | 272 | 279 | 286 | 293 | 301 | 308 | 315 | 322 | 329 | 338 | 343 | 351 | 358 | 365 | 372 | 379 | 386 | ||
72 | 265 | 272 | 279 | 287 | 294 | 302 | 309 | 316 | 324 | 331 | 338 | 346 | 353 | 361 | 368 | 375 | 383 | 390 | 397 | ||
73 | 272 | 280 | 288 | 295 | 302 | 310 | 318 | 325 | 333 | 340 | 348 | 355 | 363 | 371 | 378 | 386 | 393 | 401 | 408 | ||
74 | 280 | 287 | 295 | 303 | 311 | 319 | 326 | 334 | 342 | 350 | 358 | 365 | 373 | 381 | 389 | 396 | 404 | 412 | 420 | ||
75 | 287 | 295 | 303 | 311 | 319 | 327 | 335 | 343 | 351 | 359 | 367 | 375 | 383 | 391 | 399 | 407 | 415 | 423 | 431 | ||
76 | 295 | 304 | 312 | 320 | 328 | 336 | 344 | 353 | 361 | 369 | 377 | 385 | 394 | 402 | 410 | 418 | 426 | 435 | 443 |
Source: Adapted from Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report, National Institutes of Health, 1998.
Can medicines help reverse insulin resistance or pre-diabetes?
Clinical trials have shown that people at high risk for developing diabetes can be given treatments that delay or prevent onset of diabetes. The first therapy should always be an intensive lifestyle modification program because weight loss and physical activity are much more effective than any medication at reducing diabetes risk.
Several drugs have been shown to reduce diabetes risk to varying degrees. No drug is approved by the U.S. Food and Drug Administration to treat insulin resistance or pre-diabetes or to prevent type 2 diabetes. The American Diabetes Association recommends that metformin is the only drug that should be considered for use in diabetes prevention. Other drugs that have delayed diabetes have side effects or haven’t shown long-lasting benefit. Metformin use was recommended only for very high-risk individuals who have both forms of pre-diabetes (IGT and IFG), have a BMI of at least 35, and are younger than age 60. In the DPP, metformin was shown to be most effective in younger, heavier patients.
Points to Remember
- Insulin resistance is a condition in which the body’s cells do not use insulin properly. Insulin helps cells use blood glucose for energy.
- Insulin resistance increases the risk of developing pre-diabetes, type 2 diabetes, and cardiovascular disease.
- Pre-diabetes is a condition in which blood glucose levels are higher than normal but not high enough for a diagnosis of diabetes.
- Causes of insulin resistance and pre-diabetes include genetic factors, excess weight, and lack of physical activity.
- Being physically active, making wise food choices, and reaching and maintaining a healthy weight can help prevent or reverse insulin resistance and pre-diabetes.
- The Diabetes Prevention Program (DPP) study confirmed that people at risk for developing type 2 diabetes can prevent or delay the onset of diabetes by losing 5 to 7 percent of their body weight through regular physical activity and a diet low in fat and calories.
Hope through Research
Researchers continue to follow DPP participants to learn about the long-term effects of the study. Other research sponsored by the National Institutes of Health builds on the findings from the DPP, including research focusing on lowering diabetes risk in children. Once considered an adult disease, type 2 diabetes is becoming more common in children, and researchers are seeking ways to reverse this trend.
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors the HEALTHY study, which is part of a broad research initiative called STOPP T2D (Studies to Treat or Prevent Pediatric Type 2 Diabetes). The study seeks to improve the treatment and prevention of type 2 diabetes in youth, exploring the roles of nutrition, physical activity, and behavior change in lowering risk for type 2 diabetes in children. The participating 42 middle schools are randomly assigned to a program group implementing changes or a comparison group. Students in the program group have healthier choices from the cafeteria and vending machines; longer, more intense periods of physical activity; and activities and awareness campaigns that promote long-term healthy behaviors. Results from the HEALTHY study are expected in 2009.
The NIDDK also sponsors the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) study, which focuses on treatment of type 2 diabetes in children and teens at 13 sites. The TODAY study will evaluate the effects of three treatment approaches on control of blood glucose levels, insulin production, insulin resistance, and other outcomes. Each approach involves medication, but one of the three treatment groups will also receive an intensive lifestyle intervention to help the participants lose weight and increase physical fitness. More information about the TODAY study is available at www.todaystudy.org.
Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research. For information about current studies, visit www.ClinicalTrials.gov.
For More Information
For more information about the DPP and the risk of developing diabetes, see these publications:
These publications are available at www.diabetes.niddk.nih.gov or by calling 1–800–860–8747.
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